REVIEW: AKTIVITAS ANTIBAKTERI EKSTRAK DAUN PEGAGAN (Centella asiatica L.) TERHADAP BAKTERI GRAM POSITIF DAN GRAM NEGATIF
Gotu Kola (Centella asiatica L.) is a vine from the Umbeliferae family. Several research journals state that gotu kola has antibacterial activity. The purpose of this narrative review is to provide information regarding the antibacterial activity of Centella asiatica leaf extract against Gram-positive and Gram-negative bacteria from various solvents. The method used in writing this narrative review is online literature study through Google Scholar, Elsevier, and Science Direct. The results of the literature review stated that the diffusion method using ethanol and methanol solvents showed strong inhibition. However, using acetone and water solvent produces weak inhibition. The highest inhibition zone was shown by methanol solvent with an inhibition zone of 28 mm in Staphylococcus aureus, 29 mm in Bacillus cereus, 30 mm in Escherichia coli, and 28 mm in Pseudomonas aeruginosa. In the microdilution method, the highest antibacterial activity was shown by methanol solvent with a MIC value of 1,250 μg/mL which was in the medium category for Escherichia coli.